Figure 7.

Amelioration of apelin-13 in CNH-induced PAH and pulmonary vascular remodeling in mice. Apelin-13 treatment suppressed CNH-induced increase in RVSP (A) and RV/LV+S (B). (C) Western blotting analysis of relative proteins expression in the lungs of mice. (D) Quantification of proteins expression bands in (C) was done by densitometry and normalized to GAPDH. (E) Representative images of H&E staining of lung sections. (F) Representative Masson trichrome staining of lung section. Values shown are means±s.e.m. N=5-8 per group. *p<0.05, **p<0.01 vs. Normoxia. #p<0.05, ##p<0.01 vs. CNH. PA, pulmonary artery. BR, bronchiole.