Table 2.
Univariate and multivariate analysis of clinicopathological parameters related to overall survival in HCC patients
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≤55/ >55) | 1.268 (0.721-2.231) | 0.409 | - | - |
| Gender (Female/Male) | 0.858 (0.366-2.011) | 0.725 | - | - |
| HBV (Absent/Present) | 0.901 (0.480-1.692) | 0.746 | - | - |
| AFP (>400/≤400) | 3.949 (2.062-7.560) | 0.000*** | 3.000 (1.549-5.810) | 0.001** |
| Cirrhosis (Absent/Present) | 0.918 (0.481-1.750) | 0.795 | - | - |
| Tumor Size (>5cm/≤5cm) | 1.861 (1.077-3.215) | 0.026* | - | - |
| Tumor number (=1/>1) | 0.599 (0.344-1.043) | 0.070 | - | - |
| Vascular invasion (Positive/Negative) |
2.779 (1.577-4.900) | 0.000 | - | - |
| Tumor differentiation (Moderate-Well/Poor) |
0.375 (0.204-0.688) | 0.002** | 0.463 (0.252-0.852) | 0.013* |
| NKILA expression (High/Low) | 0.325 (0.181-0.582) | 0.000*** | 0.454 (0.251-0.822) | 0.009** |
HCC: hepatocellular carcinoma; HBV: hepatitis B virus; AFP: alpha fetoprotein.
*P < 0.05, **P < 0.01, ***P < 0.001.