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. 2020 Jan 1;16(3):504–514. doi: 10.7150/ijbs.40435

Figure 1.

Figure 1

ITPKA is over-expressed in lung adenocarcinoma (LUAD) and correlates with lymph nodes metastasis. A, volcano plot for differential expressed genes in lung adenocarcinoma (LUAD) TCGA dataset, left blue part were genes significantly downregulated in LUAD and right red part were genes significantly upregulated in LUAD, and ITPKA and TFAP2A was at a relatively hyper-expression position. B & C, ITPKA was hyper expressed in LUAD compared with normal adjacent tissues, p<0.0001, and in the 57 paired samples, there were 2 pairs with null ITPKA expression in the normal tissues (but not their counterpart adjacent tumor samples). D, lymph node positive patients had higher ITPKA expression, p=0.0229. E, the ITPKA expression were higher in advanced T stage patients, p=0.0011. F, receiver operating characteristic curve (ROC) shown ITPKA expression had a good specificity and sensitivity for diagnosis in LUAD, p<0.0001, area under curve (AUC)=0.93.