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. 2020 Jan 1;16(3):504–514. doi: 10.7150/ijbs.40435

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ITPKA is involved in epithelial mesenchymal transition (EMT). A & B, the TCGA_LUAD dataset (Top 10% ITPKA expression vs. Button 10% ITPKA expression) had been submitted for the Gene Set Enrichment Analysis (GSEA), these results indicating ITPKA was correlated with epithelial mesenchymal transition (EMT), Normalized Enrichment Score (NES)= 2.71, FDR<0.001. C, D, E & F, EMT markers were measured by qPCR and western blot, ITPKA knockdown group had lower N-Cad and Vimentin but higher E-Cad compared with their negative control group. And ITPKA overexpression groups indicated adverse results.