Table 3.
Total area under the ROC curve for potential biomarkers in discriminating the controls from patients with moderate and advanced CKD.
| Biomarker | Non-CKD (30) vs. moderate CKD (30) | Non-CKD (30) vs. advanced CKD (31) | |||
|---|---|---|---|---|---|
| AUC (95% CI) | P value/Pc value | AUC (95% CI) | P value/Pc value | ||
| Bacterial genus | |||||
| Tyzzerella 3 | 0.93 (0.85-1.00) | 1.5E-08/1.47E-06 | 0.92 (0.83-1.00) | 1.9E-08/1.862E-06 | |
| Paraprevotella | 0.76 (0.62-0.89) | 0.00062/0.06076 | 0.83 (0.73-0.93) | 1.2E-05/0.001176 | |
| Lachnospiraceae ND3007 group | 0.72 (0.59-0.86) | 0.0029/0.2842 | 0.87 (0.79-0.96) | 5.7E-07/5.586E-05 | |
| Eubacterium ruminantium group | 0.86 (0.75-0.96) | 1.9E-06/0.0001862 | 0.8 (0.68-0.92) | 5.3E-05/0.005194 | |
| Pseudobutyrivibrio | 0.72 (0.58-0.85) | 0.0037/0.3626 | 0.85 (0.75-0.95) | 6.9E-07/6.762E-05 | |
| Lactobacillus | 0.82 (0.70-0.93) | 2.6E-05/0.002548 | 0.74 (0.61-0.88) | 0.0011/0.1078 | |
| Dialister | 0.65 (0.51-0.80) | 0.041/4.018 | 0.84 (0.75-0.94) | 3.9E-06/0.0003822 | |
| Bacterial species | |||||
| Collinsella stercoris | 0.9 (0.82-0.98) | 1.0E-07/8.0E-06 | 0.86 (0.76-0.96) | 1.5E-06/0.00012 | |
| Bacteroides eggerthii | 0.88 (0.78-0.97) | 4.9E-07/3.92E-05 | 0.77 (0.65-0.90) | 0.00024/0.0192 | |
| Streptococcus anginosus | 0.85 (0.75-0.95) | 2.6E-06/0.000208 | 0.8 (0.69-0.92) | 5.1E-05/0.00408 | |
| Bacteroides clarus | 0.85 (0.75-0.95) | 2.8E-06/0.00232 | 0.66 (0.53-0.80) | 0.028/2.24 | |
| Bacteroides plebeius | 0.82 (0.70-0.93) | 2.9E-05/0.00232 | 0.82 (0.71-0.93) | 1.9E-05/0.00152 | |
| Parabacteroides goldsteinii | 0.79 (0.67-0.91) | 0.00011/0.0088 | 0.68 (0.54-0.82) | 0.017/1.36 | |
| Bacteroides massiliensis | 0.74 (0.60-0.88) | 0.0013/0.104 | 0.8 (0.69-0.92) | 5.3E-05/0.00424 | |
| Phascolarctobacterium faecium | 0.78 (0.65-0.90) | 0.00026/0.0208 | 0.69 (0.55-0.83) | 0.011/0.88 | |
| Bacteroides stercoris | 0.78 (0.64-0.91) | 0.00026/0.0208 | 0.67 (0.52-0.81) | 0.025/2 | |
| Lactobacillus salivarius | 0.8 (0.67-0.93) | 6.7E-05/0.00536 | 0.7 (0.56-0.84) | 0.0085/0.68 | |
| Ruminococcus callidus | 0.79 (0.66-0.91) | 1.4E-04/0.0112 | 0.79 (0.68-0.91) | 0.00008/0.0064 | |
| Blautia hydrogenotrophica | 0.9 (0.82-0.98) | 1.1E-07/8.8E-06 | 0.56 (0.41-0.71) | 0.44/35.2 | |
| Conventional biomarker | |||||
| Urine protein-creatinine ratio | 0.603 (0.46-0.75) | 0.169 | 0.981 (0.95-1.00) | <0.001 | |
CKD, chronic kidney disease; AUC, the total area under the ROC curve.
Corrected P (Pc) values were adjusted by using Bonferroni's correction (n=80, for species; n=98, for genus).