Table 4.
Gut bacterial genera correlated with serum levels of indoxyl sulfate or p-cresyl sulfate in discovery cohort
| Indoxyl sulfate | Total-form | Free-form | |||||
|---|---|---|---|---|---|---|---|
| Genus | R | P-value | Adjusted P | R | P-value | Adjusted P | |
| Ruminiclostridium_5 | 0.408250 | 0.000004 | 0.000245 | 0.364685 | 0.000077 | 0.004241 | |
| Dialister | -0.390723 | 0.000012 | 0.000671 | -0.410164 | 0.000007 | 0.000389 | |
| Escherichia_Shigella | 0.361672 | 0.000057 | 0.003150 | 0.413255 | 0.000006 | 0.000327 | |
| Alistipes | 0.359485 | 0.000064 | 0.003510 | 0.276417 | 0.003176 | 0.174654 | |
| unidentified_Ruminococcaceae | 0.342554 | 0.000146 | 0.008050 | 0.297251 | 0.001459 | 0.080226 | |
| Pseudobutyrivibrio | -0.338714 | 0.000176 | 0.009660 | -0.410466 | 0.000007 | 0.000383 | |
| Desulfovibrio | 0.311456 | 0.000597 | 0.032800 | 0.278645 | 0.002930 | 0.161158 | |
| Ruminococcaceae_UCG_002 | 0.301976 | 0.000890 | 0.048900 | 0.257879 | 0.006049 | 0.332694 | |
| Anaerostipes | -0.300192 | 0.000958 | 0.052700 | -0.422023 | 0.000004 | 0.000197 | |
| Ruminiclostridium | -0.291262 | 0.001375 | 0.075600 | -0.403412 | 0.000010 | 0.000568 | |
| Ruminococcaceae_UCG_004 | 0.285329 | 0.001737 | 0.095500 | 0.234490 | 0.012826 | 0.705415 | |
| Ruminococcaceae_UCG_005 | 0.278029 | 0.002301 | 0.127000 | 0.235933 | 0.012269 | 0.674768 | |
| p-Cresyl sulfate | Total form | Free form | |||||
| Genus | R | P-value | Adjusted P | R | P-value | Adjusted P | |
| Ruminiclostridium_5 | 0.447455 | <0.0001 | 0.000021 | 0.468585 | 0.000001 | 0.000033 | |
| Alistipes | 0.445359 | <0.0001 | 0.000024 | 0.400767 | 0.000027 | 0.001501 | |
| Ruminococcaceae_UCG_002 | 0.383635 | 0.000018 | 0.000990 | 0.361680 | 0.000174 | 0.009581 | |
| Ruminococcaceae_UCG_005 | 0.379890 | 0.000022 | 0.001220 | 0.372297 | 0.000108 | 0.005926 | |
| unidentified_Ruminococcaceae | 0.371433 | 0.000035 | 0.001900 | 0.284746 | 0.003555 | 0.195513 | |
| Clostridium_sensu_stricto_1 | 0.337451 | 0.000186 | 0.010200 | 0.349603 | 0.000295 | 0.016222 | |
| Ruminococcaceae_NK4A214_group | 0.320452 | 0.000404 | 0.022200 | 0.362512 | 0.000168 | 0.009233 | |
| Ruminococcaceae_UCG_004 | 0.318145 | 0.000447 | 0.024600 | 0.322497 | 0.000893 | 0.049107 | |
| Christensenellaceae_R_7_group | 0.290221 | 0.001433 | 0.078800 | 0.320379 | 0.000970 | 0.053323 | |
| Eubacterium_coprostanoligenes_gr | 0.289604 | 0.001468 | 0.080800 | 0.254246 | 0.009554 | 0.525487 | |
| Dialister | -0.281914 | 0.001983 | 0.109000 | -0.309122 | 0.001487 | 0.081799 | |
| Escherichia_Shigella | 0.278791 | 0.002235 | 0.123000 | 0.338280 | 0.000474 | 0.026084 | |
Bacterial genera present at or above 0.1% of the total were analyzed by the Spearman's rank correlation test. Corrected P values were adjusted by using Bonferroni's correction (n=55).