Figure 2.

MAIT cells in different liver diseases. In alcoholic liver disease, gut bacterial directly affect the function of MAIT cells. In nonalcoholic fatty liver disease, FFA stimulates Kupffer cells, which activates MAIT cells to produce IL-4. As a result, activated MAIT cells promote macrophage to polarize. In autoimmune liver disease, MAIT cells are a profibrogenic and proinflammatory cell population. In viral liver disease, MAIT cells exhibit cell exhaustion and impaired effector function. In liver cancer, MAIT cells show activated and exhausted phenotype. Meanwhile, MAIT cells enhance the progression of cancer. This picture was adapted from the reference ⁹².