Figure 5.

FZU-00,003 suppresses UM1 xenograft tumor growth in vivo. A-B. FZU-00,003 suppressed UM1 tumor growth in Balb/c nude mice. UM1 cells were injected into the fat pat of female Balb/c nude mice. When the average tumor size reached about 50 mm³ after inoculation, the mice were randomly and equally distributed into three groups (n=6/group): sesame oil control, 1 mg/d FZU-00,003 and 1 mg/d MIF. Tumor size was measured twice per week for 3 weeks. Tumors were collected 3 weeks after drug treatment. C. FZU-00,003 significantly decreased tumor weights compared to the MIF and control groups (*, p<0.05,**, p<0.01,t-test). D. Both FZU-00,003 and MIF did not affect the body weight of the mice. The mice were weighed at the end of the experiment.