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. 2020 Jan 1;16(4):583–597. doi: 10.7150/ijbs.39936

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Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer cells. A. Western blotting showed that aspirin can activate AMPKα phosphorylation and inhibit p-mTOR expression in AU-565 (left) and BT-474 (right) cells. B. Compound C successfully inhibited the expression of p-AMPK elevated by aspirin in AU-565 (top) and BT-474 (bottom) cells. C. An MTT assay showed that Compound C (10 μmol/L, 4 h), combined with aspirin, reduced cell viability to a greater extent in AU-565 (top) and BT-474 (bottom) cells. D. Compound C enhanced the aspirin-induced inhibition of AU-565 and BT474 cell colony formation ability. E. Flow cytometry showed that Compound C promoted aspirin-induced apoptosis in AU-565 and BT-474 breast cancer cells. *P < 0.05; **P < 0.01; ***P < 0.001 vs. control.