Table 2. Comparison of Hemodynamic Variables Stratified According to Randomization.
| Hemodynamic Variables | Mean (SD) | P Value | |
|---|---|---|---|
| General Anesthesia (n = 182) | Procedural Sedation (n = 183) | ||
| Baseline values, mm Hg | |||
| SBP | 162 (25) | 165 (27) | .31 |
| MABP | 111 (16) | 113 (18) | .49 |
| Periprocedural variables, mm Hg | |||
| MABP during procedure | 96 (10) | 100 (11) | .01 |
| SBP during procedure | 143 (15) | 149 (17) | .15 |
| Minimum MABP during procedure | 76 (14) | 86 (15) | .04 |
| Maximum MABP during procedure | 120 (15) | 119 (16) | .83 |
| Minimum SBP during procedure | 111 (21) | 126 (23) | .10 |
| Maximum SBP during procedure | 178 (21) | 176 (23) | .38 |
| No. of patients and time less than specified MABP and SBP thresholds during procedure | |||
| 20% Drop in MABP during procedure, No. (%) | 143 (79) | 93 (51) | <.001 |
| 20% Drop in SBP during procedure, No. (%) | 140 (77) | 90 (49) | <.001 |
| Patients with systolic blood pressure less than 140 mm Hg, No. (%) | 167 (92) | 132 (72) | <.001 |
| Patients with MABP <90 mm Hg, No. (%) | 148 (81) | 106 (58) | <.001 |
| Cumulated time with MABP <90 mm Hg, min | 35 (37) | 24 (32) | .11 |
| Longest continuous episode with MABP <90 mm Hg, min | 24 (27) | 17 (24) | .05 |
| Patients with MABP <80 mm Hg, No. (%) | 109 (60) | 56 (31) | <.001 |
| Cumulated time with MABP <80 mm Hg, min | 15 (20) | 9 (18) | .12 |
| Longest continuous episode with MABP 80 mm Hg, min | 11 (13) | 6 (13) | .06 |
| Patients with MABP <70 mm Hg, No. (%) | 58 (32) | 26 (14) | <.001 |
| Cumulated time with MABP <70 mm Hg, min | 5 (10) | 2 (8) | .07 |
| Longest continuous episode with MABP <70 mm Hg, min | 4 (6) | 2 (6) | .046 |
| No. of patients and time greater than specified MABP thresholds during procedure | |||
| Patients with MABP >90 mm Hg, No. (%) | 182 (100) | 177 (97) | .030 |
| Cumulated time with MABP >90 mm Hg, min | 75 (51) | 87 (62) | .33 |
| Longest continuous episode with MABP >90 mm Hg, min | 58 (47) | 71 (57) | .21 |
| Patients with MABP >100 mm Hg, No. (%) | 169 (93) | 165 (90) | .45 |
| Cumulated time with MABP >100 mm Hg, min | 43 (46) | 58 (56) | .14 |
| Longest continuous episode with MABP >100 mm Hg, min | 29 (38) | 40 (45) | .12 |
| Patients with MABP >110 mm Hg | 124 (68) | 129 (70) | .65 |
| Cumulated time with MABP >110 mm Hg, min | 18 (28) | 27 (38) | .06 |
| Longest continuous episode with MABP >110 mm Hg, min | 11 (19) | 17 (25) | .005 |
| Blood pressure variability and use of vasopressors | |||
| Δ MABP, mm Hga | 17.4 (12.1) | 14.8 (12.9) | .39 |
| Use of vasopressors, No. (%) | 180 (99) | 108 (59) | <.001 |
Abbreviations: EVT, endovascular therapy; Δ MABP, change in MABP; MABP, mean arterial blood pressure; SBP, systolic blood pressure.
a
Δ MABP was calculated as the difference between baseline MABP and the mean of all MABP values measured during the procedure. Cumulated time less than or greater than a given threshold is defined as the total cumulative duration of minutes less than or greater than the threshold during the EVT procedure. Longest continuous episode is defined as the longest continuous period in minutes less than or greater than a given threshold during the EVT procedure.