Figure 2. Association Between Podophyllotoxin Use During Pregnancy and Adverse Fetal Safety Outcomes.

Each podophyllotoxin-exposed pregnancy was matched with 10 unexposed pregnancies according to propensity scores. The gestational day on podophyllotoxin exposure (index date) was added as an additional matching criterion for the analyses of spontaneous abortions and stillbirths.

^aLogistic regression was used to estimate the prevalence odds ratios (ORs) of major birth defects, preterm births, and small-for-gestational-age newborns. The Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) of spontaneous abortions and stillbirths.