Table 2. Sensitivity Analyses of Podophyllotoxin Use During Pregnancy and Risk of Major Birth Defects.
| Major Birth Defects | No. With Major Birth Defects/Total No. (%) | Prevalence Odds Ratio (95% CI) |
|---|---|---|
| Compared with podophyllotoxin use in past 2 y before pregnancy only, matched in a 1:2 ratio | ||
| Podophyllotoxin exposure in pregnancy | 28/838 (3.3) | 0.92 (0.58-1.44) |
| Podophyllotoxin use 2 y before pregnancy onlya | 61/1676 (3.6) | 1 [Reference] |
| Podophyllotoxin exposure during gestational day 0-84 | ||
| Exposed | 19/611 (3.11) | 0.91 (0.57-1.46) |
| Unexposed | 286/8390 (3.4) | 1 [Reference] |
| Podophyllotoxin exposure in gestational wk 4-10 | ||
| Exposed | 7/261 (2.7) | 0.78 (0.37-1.67) |
| Unexposed | 286/8390 (3.4) | 1 [Reference] |
| Podophyllotoxin exposure through entire pregnancy | ||
| Exposed | 42/1156 (3.6) | 0.98 (0.71-1.35) |
| Unexposed | 428/11 560 (3.7) | 1 [Reference] |
| Podophyllotoxin exposure in 2nd and 3rd trimester only | ||
| Exposed | 14/318 (4.4) | 1.20 (0.70-2.07) |
| Unexposed | 428/11 560 (3.7) | 1 [Reference] |
| Singleton pregnancies only | ||
| Exposed | 26/809 (3.2) | 0.98 (0.65-1.48) |
| Unexposed | 267/8165 (3.3) | 1 [Reference] |
a
Women with filled prescriptions for local podophyllotoxin in the period from 2 years until 3 months before pregnancy but with no filled prescriptions during the 3 months before pregnancy or in pregnancy.