Table 3. Sensitivity Analyses of Podophyllotoxin Use During Pregnancy and Risk of Spontaneous and Induced Abortion.
| Sensitivity Analyses | No. With Outcome/Total No. (%) | Hazard Ratio (95% CI) |
|---|---|---|
| Spontaneous abortion | ||
| Compared with podophyllotoxin use in past 2 y before pregnancy only, matched in a 1:2 ratio | ||
| Podophyllotoxin exposure in pregnancy | 141/1690 (8.3) | 0.89 (0.73-1.09) |
| Podophyllotoxin use 2 y before pregnancy onlya | 318/3380 (9.4) | 1 [Reference] |
| Podophyllotoxin exposure during gestational days 0-154 | ||
| Exposed | 108/1325 (8.2) | 0.89 (0.73-1.09) |
| Unexposed | 1227/13 250 (9.3) | 1 [Reference] |
| Induced abortion | ||
| Induced abortions overall | ||
| Exposed | 587/1690 (34.7) | 1.15 (1.05-1.25) |
| Unexposed | 5081/16 900 (30.1) | 1 [Reference] |
| Post hoc analyses | ||
| Induced abortions before end of gestational wk 12 (wk 6-12) | ||
| Exposed | 567/1690 (33.6) | 1.15 (1.06-1.26) |
| Unexposed | 4870/16 900 (28.8) | 1 [Reference] |
| Induced abortions later than gestational wk 12 (wk 13-22) | ||
| Exposed | 20/1690 (1.2) | 1.01 (0.64-1.60) |
| Unexposed | 211/16 900 (1.3) | 1 [Reference] |
| Birth defects among induced abortions in a subcohort, 2004-2016 | ||
| Exposed | 2/1238 (0.2) | 0.65 (0.15-2.72) |
| Unexposed | 28/11 239 (0.3) | 1 [Reference] |
a
Women with filled prescriptions for local podophyllotoxin in the period from 2 years until 3 months before pregnancy but with no filled prescriptions during the 3 months before pregnancy or in pregnancy.