. 2020 Jan 27;8:e8454. doi: 10.7717/peerj.8454

Table 3. Independent risk factors of overall survival.

Characteristics	Univariate		Multivariate
	HR(95% CI)	P value	HR(95% CI)	P value
Age, year	0.997(0.986,1.007)	0.529
Sex: female vs. male	0.980(0.757,1.269)	0.878
AFP, ng/mL	1.001(1.000,1.001)	0.011
CEA, ng/mL	1.000(0.999,1.001)	0.886
CA199, ng/mL	1.001(1.001,1.001)	<0.001	1.001(1.000,1.001)	0.002
TBIL, µmol/L	1.000(0.997,1.003)	0.942
ALB, g/L	0.953(0.928,0.979)	<0.001	0.965(0.939,0.992)	0.012
ALT, U/L	1.001(0.999,1.003)	0.381
GGT, U/L	1.000(1.000,1.001)	0.368
ALP, U/L	1.001(1.000,1.002)	0.014
HBsAg: positive vs. negative	0.844(0.670,1.063)	0.150
Tumor size, cm	1.068(1.040,1.098)	<0.001	1.039(1.007,1.072)	0.015
Tumor number: multiple vs. single	1.908(1.467,2.481)	<0.001	1.604(1.217,2.115)	0.001
Surgical margin: <1 cm vs. ≥1 cm	1.273(0.976,1.660)	0.075
Liver cirrhosis: positive vs. negative	0.900(0.693,1.169)	0.429
MVI: positive vs. negative	1.725(1.330,2.238)	<0.001	1.345(1.026,1.763)	0.032
TNM: III–IV vs. I–II	1.865(1.385,2.511)	<0.001	1.578(1.142,2.181)	0.006
UBE2T: high vs. low	1.609(1.259,2.057)	<0.001	1.420(1.098,1.837)	0.008

Notes.