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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Arch Toxicol. 2019 Apr 20;93(6):1501–1513. doi: 10.1007/s00204-019-02450-5

Table 2.

Comparison of lung deposited PM mass (μg PM) and lung toxicity potencies (# neutrophil/μg PM) after inhalation and aspiration of biomass smoke PM.

Exposure method Peat Eucalyptus Oak
Smoldering Flaming Smoldering Flaming Smoldering Flaming
Deposited PM mass
Aspiration1) 81 81 81 81 81 81
Inhalation2) 65.8±1.8 6.1±0.2 60.9±2.0 5.5±0.3 97.1±9.7 9.2±0.7
Lung toxicity potency
Aspiration3) 4 h 39±14* 294±173* 105±33* 209±52* 27±12 88±52*
24 h 41±12 846±274* 94±35* 782±527* 70±52 17±7
Inhalation4) 4h 41±7* 454±78* 64±9* 321±70 25±5 203±44
24h 68±15 1,208±332* 53±18 589±144* 21±6 333±59

Note: Error ranges represent standard error of the mean (SEM)

1)

Deposited PM mass = PM deposition fraction in the respiratory tract (Foster et al. 2001) × PM dose (Kim et al. 2018)

2)

Deposited PM mass = PM deposition fraction in the respiratory tract (Figure 7A) × PM dose (Table 1) × Total respiratory volume (Table S4)

3)

Lung toxicity potency = Neutrophil counts (Kim et al. 2018) / Deposited PM mass

4)

Lung toxicity potency = Neutrophil counts (Figure 5B) / Deposited PM mass

*

These values were statistically significant from the respective negative control groups.