| Date | Event | Description |
|---|---|---|
| 8 November 2007 | New search has been performed | 8 November 2007: an update search was run which did not identify any newly reported trials since this review was last updated in 2005. |
| 20 May 2005 | Amended | May 2005: Sigma Tau provided many additional company reports which allowed us to identify and include additional trials. The data provided by Sigma‐Tau in the reports allowed us to include these new trials in the meta‐analysis. This did not have any overall effect on the conclusions, but improves their reliability. |
| 21 February 2003 | New citation required and conclusions have changed | Substantive amendment |
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