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. 2006 Oct 18;2006(4):CD003727. doi: 10.1002/14651858.CD003727.pub3
Study Reason for exclusion
Adler 1987 Allocation: not randomised.
Adler 1988 Allocation: not randomised.
Adler 1993 Allocation: randomised. 
 Participants: people with chronic schizophrenia, schizoaffective disorder, major depression with psychosis. 
 Interventions: propanolol versus benztropine versus placebo. 
 Outcomes: no usable data, 9 of 28 participants were given concomitant benzodiazepines, no seperate data available.
Friss 1983 Allocation: randomised, cross‐over design. 
 Participants: people whose diagnosis was not specified, suffering from neuroleptic‐induced akathisia. 
 Interventions: valproate versus biperiden versus placebo. 
 Outcomes: no data about allocation in first period. Dr Gerlach (author) contacted and replied promptly; data were destroyed and no more information is available.
Gagrat 1978 Allocation: randomised. 
 Participants: people with psychotic disorders, suffering from neuroleptic‐induced akathisia. 
 Interventions: benzodiazepine versus diphenhydramine, none versus placebo.
Hermesh 1988 Allocation: not randomised, not controlled clinical trial.
Hirose 2000 Allocation: unclear. 
 Participants: people with psychotic disorders, suffering from neuroleptic‐induced akathisia. 
 Interventions: biperiden at different dosages.
Horiguchi 1992 Allocation: randomised. 
 Participants: people with schizophrenia, suffering from neuroleptic‐induced akathisia. 
 Interventions: benzodiazepine versus anticholinergic, none versus placebo.
Neu 1972 Allocation: randomised. 
 Participants: people with psychotic disorders, suffering from neuroleptic‐induced akathisia. 
 Interventions: anticholinergic versus anticholinergic, none versus placebo.
Sachdev 1993 Allocation: randomised. 
 Participants: people with schizophrenia, suffering from neuroleptic‐induced akathisia. 
 Interventions: benztropine (iv) versus propranolol (iv) versus placebo (iv). 
 Outcomes: no usable data, two of the 6 participants were taking benzodiazepines, no separate data available.
Zeng 1995 Allocation: unclear. 
 Participants: people suffering from neuroleptic‐induced akathisia. 
 Interventions: dexetimide versus benzhexolum, no placebo group.