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. 2019 Oct 10;28(24):4053–4066. doi: 10.1093/hmg/ddz225

Figure 3.

Figure 3

Genetic reduction of Adamts9 in B3glct mutants impaired eye development.

(A–D′) Comparison of eyes from B3glct-Δ11-12 heterozygotes (Δ11–12/+) (A-B′) and homozygotes (Δ11–12/Δ11-12) (C–D′) using OCT at 21 days of age. Scanned region is indicated by rectangle in (A–D). A′–D′ OCT sections at level indicated by the line bisecting rectangle panels in A–D. (E, E′) Range of eye phenotypes observed in E18.5 B3glct-Δ11–12 homozygotes missing one copy of Adamts9 (B3glct-Δ11-12/Δ11-12;Adamts9 del/+). Eye size was determined by measuring maximum pigmented diameter and pupil size by measuring maximum pupil diameter. (F, G) Comparison of the effects of reducing Adamts9 in B3glct-Δ11-12 heterozygotes and homozygotes on eye (F) and pupil (G) size. Eye size was categorized as small if measurements were less than 1 standard deviation from the mean of B3glct-Δ11-12 heterozygous controls. *P ≤ 0.05, **P ≤ 0.01 using Chi-square test.