Table 2. Estimated Annual Rate of Change of Cerebrospinal Fluid Levels of tTau and pTau181 and Structural Magnetic Resonance Imaging (Regions of Interest) in Mutation Carriers by Estimated Years Before Onset^a.

Estimated Time Before Onset, y	tTau		pTau181		Entorhinal Thickness		Hippocampal Volume		Precuneus Thickness		Superior Frontal Thickness
	Rate of Change, Mean (SE)	P Value	Rate of Change, Mean (SE)	P Value	Rate of Change, Mean (SE)	P Value	Rate of Change, Mean (SE)	P Value	Rate of Change, Mean (SE)	P Value	Rate of Change, Mean (SE)	P Value
−25	0.3 (3.8)	.94	0.1 (0.5)	.88	0.011 (0.012)	.33	5.6 (29.0)	.85	−0.004 (0.004)	.37	−0.006 (0.006)	.32
−20	2.9 (2.7)	.28	0.6 (0.3)	.09	−0.002 (0.009)	.83	−23.9 (21.7)	.27	−0.008 (0.003)	.01	−0.008 (0.005)	.09
−15	5.4 (3.9)	.17	1.1 (0.5)	.03	−0.015 (0.007)	.04	−53.5 (17.9)	.004	−0.012 (0.003)	<.001	−0.010 (0.004)	.02
−10	5.5 (2.8)	.05	0.7 (0.3)	.04	−0.028 (0.009)	.001	−83.0 (19.9)	<.001	−0.016 (0.004)	<.001	−0.011 (0.005)	.02
−5	5.5 (2.1)	.01	0.4 (0.3)	.15	−0.041 (0.012)	<.001	−112.5 (26.4)	<.001	−0.020 (0.005)	<.001	−0.013 (0.006)	.04
0	5.6 (2.3)	.02	0.1 (0.3)	.83	−0.066 (0.010)	<.001	−232.9 (20.9)	<.001	−0.048 (0.003)	<.001	−0.022 (0.005)	<.001
5	5.6 (3.2)	.08	−0.3 (0.4)	.51	−0.106 (0.018)	<.001	−413.9 (34.4)	<.001	−0.075 (0.005)	<.001	−0.036 (0.008)	<.001
10	5.7 (4.4)	.20	−0.6 (0.6)	.28	−0.147 (0.033)	<.001	−594.9 (61.6)	<.001	−0.103 (0.009)	<.001	−0.050 (0.014)	<.001

Abbreviations: pTau181, phosphorylated tau 181; tTau, total tau.

^aP values were for testing whether the rate of change is significantly different from 0.