Table 2. Cox Proportional HRs for Leukocyte Subtypes (Comparing Above vs Below the Median Proportion) and Breast Cancer, With Age as the Timescalea.
| Variable | Model 1b | Model 2c | Model 3d | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Events, No./participants, No. | 1569/2773 | 1569/2772 | 1550/2727 | |||
| Lymphocytes | ||||||
| B cells | 1.17 (1.01-1.36) | .04 | 1.16 (1.00-1.35) | .05 | 1.17 (1.00-1.37) | .05 |
| Natural killer | 1.03 (0.89-1.20) | .70 | 1.03 (0.88-1.20) | .72 | 1.02 (0.87-1.19) | .84 |
| T cells | ||||||
| CD8+ | 1.07 (0.92-1.24) | .38 | 1.07 (0.92-1.24) | .38 | 1.13 (0.96-1.32) | .14 |
| CD4+ | 1.09 (0.94-1.27) | .26 | 1.09 (0.93-1.26) | .29 | 1.11 (0.95-1.30) | .18 |
| Myelocytes | ||||||
| Monocytes | 0.90 (0.77-1.04) | .16 | 0.90 (0.77-1.05) | .17 | 0.87 (0.75-1.02) | .09 |
| Granulocytes | 0.91 (0.78-1.05) | .20 | 0.91 (0.78-1.06) | .21 | 0.90 (0.77-1.05) | .19 |
| Methylation-derived neutrophil-to-lymphocyte ratio | 0.91 (0.78-1.06) | .23 | 0.91 (0.78-1.06) | .24 | 0.90 (0.77-1.05) | .18 |
Abbreviation: HR, hazard ratio.
a
One woman from the random subcohort received a diagnosis of ductal carcinoma in situ and was missing follow-up time.
b
Model 1 is crude, with age as the timescale.
c
Model 2 is adjusted for baseline menopause status, with age as the timescale.
d
Model 3 is adjusted for breast cancer risk factors, including age at enrollment, baseline body mass index (calculated as the weight in kilograms divided by height in meters squared), menopause status, an interaction term for body mass index and menopause, physical activity, alcohol intake, parity, age at first birth (among parous women), age at menarche, breastfeeding duration, and hormone therapy and oral contraception duration, with age as the timescale.