Summary of findings 3. Trauma‐focused CBT/Exposure therapy compared with other therapies for chronic post‐traumatic stress disorder (PTSD) in adults.
| Trauma‐focused CBT/Exposure therapy compared with other therapies for chronic post‐traumatic stress disorder (PTSD) in adults | ||||||
| Patient or population: Adults with PTSD for at least 3 months Settings: Primary care, community, outpatient Intervention: Trauma‐focused CBT/Exposure therapy Comparison: other therapies | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Other Therapies | Trauma Focused CBT/Exposure Therapy | |||||
| Severity of PTSD symptoms ‐ Clinician‐rated | The mean severity of PTSD symptoms ‐ clinician in the intervention groups was | ‐0.48 standard deviations lower (‐0.83 to ‐0.43 lower) | 612 (10 studies) | ⊕⊝⊝⊝ very low1,2,3 | ||
| Leaving the study early for any reason | Study population | RR 1.39 (1.01 to 1.92) | 762 (11 studies) | ⊕⊝⊝⊝ very low1,2,3 | ||
| 142 per 1000 | 198 per 1000 (144 to 274) | |||||
| Moderate | ||||||
| 138 per 1000 | 192 per 1000 (139 to 265) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Some studies were judged to pose a high risk of bias 2Unexplained heterogeneity 3Small sample sizes