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. 2019 Dec 26;105(3):644–659. doi: 10.1210/clinem/dgz115

Table 2.

Twenty-Two Kinases With a Significant Difference in Their Activity in Skeletal Muscle Tissue in OIR Compared With Lean

Gene Name Protein Name Fold Change OIR/Lean Main Pathway/Function
MAPK12 Mitogen-activated protein kinase 12 Infinitesimala p38 MAPK
MAPK13 Mitogen-activated protein kinase 13 Infinitesimal p38 MAPK
RPS6KA3 Ribosomal protein S6 kinase alpha-3 Infinitesimal MAPK/ERK; mTOR
CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 0.06 ± 0.04 Calcium signaling
STK11 (LKB1) Serine/threonine-protein kinase STK11 0.07 ± 0.04 AMPK; mTOR
PRKAA1(AMPK1) 5’-AMP-activated protein kinase catalytic subunit alpha-1 0.14 ± 0.04 AMPK; mTOR
PRKAA2 (AMPK2) 5’-AMP-activated protein kinase catalytic subunit alpha-2 0.14 ± 0.04 AMPK; mTOR
MARK3 MAP/microtubule affinity-regulating kinase 3 0.14 ± 0.09 AMPK
MARK4 0.14 ± 0.09 AMPK; mTOR
GSK3A Glycogen synthase kinase-3 alpha 0.22 ± 0.09 Glucose Homeostasis
ULK3 Serine/threonine-protein kinase ULK3 0.44 ± 0.13 SHH signaling
MAP2K4(MKK4) Dual specificity mitogen-activated protein kinase kinase 4 0.20 ± 0.06 JNK
CSNK1A1(CK1) Casein kinase I isoform alpha Infiniteb Wnt/NF-κB
CSNK2A1(CK2) Casein kinase II subunit alpha Infinite Wnt/NF-κB
MAP3K2 (MEKK2) Mitogen-activated protein kinase kinase kinase 2 Infinite JNK
MAP3K3 (MEKK3) Mitogen-activated protein kinase kinase kinase 3 Infinite JNK
MAP4K4 (HGK) Mitogen-activated protein kinase kinase kinase kinase 4 Infinite JNK
MINK1 Misshapen-like kinase 1 Infinite JNK
NEK9 Serine/threonine-protein kinase Nek9 Infinite Cell Division
STK24 (MST3) Serine/threonine-protein kinase 24 Infinite JNK
STK38 (NDR1) Serine/threonine-protein kinase 38 Infinite JNK
STK38L (NDR2) Serine/threonine-protein kinase 38-like Infinite JNK
TNIK TRAF2 and NCK-interacting protein kinase Infinite JNK/Wnt

aIndicates the active kinase is only identified in Lean.

bIndicates the active kinase is only identified in OIR.