Table 2.
Twenty-Two Kinases With a Significant Difference in Their Activity in Skeletal Muscle Tissue in OIR Compared With Lean
| Gene Name | Protein Name | Fold Change OIR/Lean | Main Pathway/Function |
|---|---|---|---|
| MAPK12 | Mitogen-activated protein kinase 12 | Infinitesimala | p38 MAPK |
| MAPK13 | Mitogen-activated protein kinase 13 | Infinitesimal | p38 MAPK |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Infinitesimal | MAPK/ERK; mTOR |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | 0.06 ± 0.04 | Calcium signaling |
| STK11 (LKB1) | Serine/threonine-protein kinase STK11 | 0.07 ± 0.04 | AMPK; mTOR |
| PRKAA1(AMPK1) | 5’-AMP-activated protein kinase catalytic subunit alpha-1 | 0.14 ± 0.04 | AMPK; mTOR |
| PRKAA2 (AMPK2) | 5’-AMP-activated protein kinase catalytic subunit alpha-2 | 0.14 ± 0.04 | AMPK; mTOR |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.14 ± 0.09 | AMPK |
| MARK4 | 0.14 ± 0.09 | AMPK; mTOR | |
| GSK3A | Glycogen synthase kinase-3 alpha | 0.22 ± 0.09 | Glucose Homeostasis |
| ULK3 | Serine/threonine-protein kinase ULK3 | 0.44 ± 0.13 | SHH signaling |
| MAP2K4(MKK4) | Dual specificity mitogen-activated protein kinase kinase 4 | 0.20 ± 0.06 | JNK |
| CSNK1A1(CK1) | Casein kinase I isoform alpha | Infiniteb | Wnt/NF-κB |
| CSNK2A1(CK2) | Casein kinase II subunit alpha | Infinite | Wnt/NF-κB |
| MAP3K2 (MEKK2) | Mitogen-activated protein kinase kinase kinase 2 | Infinite | JNK |
| MAP3K3 (MEKK3) | Mitogen-activated protein kinase kinase kinase 3 | Infinite | JNK |
| MAP4K4 (HGK) | Mitogen-activated protein kinase kinase kinase kinase 4 | Infinite | JNK |
| MINK1 | Misshapen-like kinase 1 | Infinite | JNK |
| NEK9 | Serine/threonine-protein kinase Nek9 | Infinite | Cell Division |
| STK24 (MST3) | Serine/threonine-protein kinase 24 | Infinite | JNK |
| STK38 (NDR1) | Serine/threonine-protein kinase 38 | Infinite | JNK |
| STK38L (NDR2) | Serine/threonine-protein kinase 38-like | Infinite | JNK |
| TNIK | TRAF2 and NCK-interacting protein kinase | Infinite | JNK/Wnt |
aIndicates the active kinase is only identified in Lean.
bIndicates the active kinase is only identified in OIR.