Table 1.
Effect of allopurinol on general characteristics in controls and rats with streptozotocin‐induced diabetes
| Parameters | C | D | DA |
|---|---|---|---|
| Water intake (mL/kg/d) | 120.6 ± 2.5 | 790.4 ± 11.2* | 679 ± 10*, # |
| Food consumption (g/kg/d) | 65.5 ± 4.5 | 180.1 ± 12.3* | 179.7 ± 8.5* |
| Plasma glucose (mmol/L) | 7.3 ± 0.3 | 29.5 ± 1.5* | 30.3 ± 1.2* |
| Body weight (g) | 476.2 ± 5.0 | 343.3 ± 4.5* | 341.2 ± 6.0* |
| Heart weight (g) | 1.15 ± 0.03 | 0.96 ± 0.02* | 0.96 ± 0.04* |
| Heart/Body weight ratio (g/kg) | 2.42 ± 0.07 | 2.81 ± 0.05* | 2.82 ± 0.11* |
Water intake and food consumption were the average value of 4 wk. Body weight and plasma glucose were measured at termination. Control (C), diabetes (D), diabetes treated with allopurinol (DA). Data are expressed as mean ± SEM (n = 6 per group).
*
P < .05 vs C.
#
P < .05 vs D