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. 2019 Dec 27;24(2):1848–1865. doi: 10.1111/jcmm.14881

Figure 2.

Figure 2

HBx protein contributes to lncRNA F11‐AS1 down‐regulation in HCC cells. A, lncRNA F11‐AS1 expression in HepG2.2.15 cells after plasmid delivery of pUC18‐HBV1.3copy, pUC18, si‐HBx and si‐NC determined by RT‐qPCR; * P < .05 vs HepG2.2.15 cells delivered with pUC18.  # P <.05 vs HepG2.2.15 cells delivered with si‐NC. B, lncRNA F11‐AS1 expression in HepG2.2.15 cells after the delivery of pCD3‐FLAG/HBx, pCD3‐FLAG/HBc, pCD3‐FLAG/HBs, pCD3‐FLAG/HBV polymerase and pCD3‐FLAG measured by RT‐qPCR; * P < .05 vs HepG2.2.15 cells delivered with pCD3‐FLAG. C, Correlation between lncRNA F11‐AS1 expression and HBx mRNA expression in patients with HBV+ HCC analysed by Pearson's correlation coefficient analysis. Data were measurement data and expressed by mean ± standard deviation. Comparison of data between the two groups was analysed by unpaired t test, and that among multiple groups was examined by one‐way analysis of variance followed by Tukey's post hoc test. Pearson's correlation coefficient was applied for Pearson's correlation analysis