Figure 9.

lncRNA F11‐AS1 up‐regulates the expression of NR1I3 via miR‐211‐5p to hinder the progression of HBV‐related HCC. In HBV‐related HCC, HBV‐encoded HBx protein inhibited the expression of lncRNA F11‐AS1. lncRNA F11‐AS1 could up‐regulate NR1I3 via binding to miR‐211‐5p, whereas down‐regulation of lncRNA F11‐AS1 caused by HBx protein weakened its ability to bind to miR‐211‐5p, which could target to decrease NR1I3 expression. As a result, the proliferation, migration and invasion of HBV‐related HCC cells were enhanced, yet cell apoptosis was attenuated. Importantly, overexpression of lncRNA F11‐AS1 could enhance the NR1I3 expression by acting as a ceRNA of miR‐211‐5p, ultimately impeding the progression of HBV⁺ HCC