Table 1.
List of significantly up‐ or down‐regulated regulated canonical pathways that were significantly related to differentially expressed genes (DEGs) between NC and PNO1 KD T24 cells
| Ingenuity canonical pathways | −log(P‐value) | Z‐score |
|---|---|---|
| Colorectal Cancer Metastasis Signalling | 2.32 | −3.53 |
| PCP pathway | 2.19 | −3 |
| HMGB1 Signalling | 3.5 | −2.982 |
| Role of IL‐17F in Allergic Inflammatory Airway Diseases | 2.79 | −2.828 |
| TREM1 Signalling | 2.09 | −2.714 |
| IL‐6 Signalling | 3.78 | −2.683 |
| IL‐1 Signalling | 2.72 | −2.53 |
| 4‐1BB Signalling in T Lymphocytes | 2.53 | −2.449 |
| Toll‐like Receptor Signalling | 2.14 | −2.333 |
| Acute‐Phase Response Signalling | 4.54 | −2.236 |
| Leucocyte Extravasation Signalling | 1.79 | −2.236 |
| Cardiac Hypertrophy Signalling | 1.79 | −2.132 |
| Dendritic Cell Maturation | 1.44 | −2.065 |
| IL‐8 Signalling | 3.07 | −2.041 |
| Inflammasome pathway | 1.38 | −2 |
| PPAR Signalling | 1.45 | 2.714 |
−log(P‐value) > 1.3, which meant P < .05, represented significant correlation between DEGs and the pathway. Z‐score > 2 suggested significant activation of the pathway while Z‐score < −2 suggested significant repression of the pathway.