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. 2019 Dec 12;24(2):1866–1877. doi: 10.1111/jcmm.14882

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© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effect of SB525334 on KLF4 overexpression‐induced mesenchymal phenotypes of Lgr5⁺CD44⁺EpCAM⁺ cells. A, SB525334 decreased expression of TGF‐β1 detected by using immunofluorescence staining and laser confocal microscopy. Scale bars, 30 μm. B, SB525334 decreased the expression of TGF‐β1, p‐Smad2, p‐Smad3 protein and increased Smad4 protein. C, SB525334 decreased expression of N‐cad, Vim, Snail, Slug proteins, and increased expression of E‐cad and ZO‐1 proteins. D, SB525334 decreased the migration and invasion capabilities of KLF4 overexpressed CSCs detected by using the real‐time migration and invasion assay and Transwell migration and invasion assay, respectively. Scale bars = 20 μm. The data represented as mean ± SD of three replicated experiments (*P < .05)