Figure 1.

Deoxycorticosterone acetate (DOCA)‐salt treatment induced hypertension, albuminuria and kidney injury. (A) The systolic blood pressure (SBP) in DOCA‐salt‐induced hypertensive mice was monitored by a tail‐cuff. Urinary albumin (B) levels were elevated by treatment with DOCA for 14 d. The values are presented as the mean ± SE, n = 6 mice/group, *P < .05, **P < .01 vs the control group. (C) Representative images of Masson's trichrome‐stained kidney sections from the control and DOCA‐salt‐treated mice showed gradually aggravated tubular dilatation/atrophy (*), epithelial cell necrosis, interstitial oedema and fibrosis (blue). Scale bar: 50 μm