Table 2.

Univariate and multivariate analysis of the correlation of prognosis with ER and clinicopathologic data in GBC

	Univariable analysis		Multivariable analysis
	HR (95% CI)	P‐value	HR (95% CI)	P‐value
Sex (male vs female)	0.748 (0.481‐1.164)	.199
Age (<65 vs ≥65)	0.873 (0.582‐1.310)	.511
Tumour size (≥4 cm vs <4 cm)	1.778 (1.173‐2.695)	.007*	1.427 (0.904‐2.252)	.126
Histological grade (III‐IV vs I‐II)	1.503 (1.004‐2.250)	.048*	1.487 (0.990‐2.234)	.056
TNM stage (III‐IV vs I–II)	1.946 (1.258‐3.010)	.003*	1.717 (0.997‐2.958)	.051
Lymph node metastasis (presence vs absence)	1.600 (1.049‐2.441)	.029*	1.106 (0.657‐1.859)	.705
Distant metastasis (presence vs absence)	1.806 (1.196‐2.728)	.005*	1.083 (0.606‐1.936)	.788
ER expression (high vs low)	1.799 (1.160‐2.790)	.009*	1.685 (1.071‐2.651)	.024*

P < .05 was considered statistically significant.

Abbreviations: CI, confidence interval; HR, hazard ratio.

^* P < .05.