Figure 1.

HMGB1 was highly expressed and underwent nucleocytoplasmic translocation in lung macrophages from COPD patients. A, Representative immunohistochemistry of HMGB1 in lung tissues of COPD, Smoker and Non‐smoker groups. Bar: 100 μm. B, The integrated optical density (IOD) in immunohistochemistry of HMGB1. C, Level of HMGB1 was measured in serum. D, Representative immunofluorescence of co‐localization of HMGB1 and CD68 in lung tissue of COPD, Smoker and Non‐smoker groups. Bar: 25 μm. ^# P < .05. N = 15 in each group. ^# P < .05. Values are mean ± SEM