Fig. 11.

Electrophysiological signals predicting acute and real-time tissue responses. (a) Fraction of animals with acutely reduced or increased tSR in acute and chronic groups, respectively, at 4 and 8 dpi. More animals showed reduced tSR in the acute group. (b) Mean tSR change ratio of acute and chronic groups from 1 dpi to 4 and 8 dpi. (c) Animals with acutely reduced total SR have significantly higher tSR at 1 dpi compared with those with acutely increased tSR. (d)–(g) The significant correlations between electrophysiological data (tSR and high-gamma signal) and tissue responses (percentage of cells relative to maximum number of cells in the field, and ROI pixel sum in angiographs, within $100\mu \mathrm{m}$ of electrode) at chronic time points. Left panels show the time course of the two correlated features. Right panels show the Pearson’s correlation between the two features. Only chronic data ($>30\mathrm{dpi}$) were analyzed for Pearson’s correlation.