Fig. 6.

Transected dendrites in the electrode path atrophy over time. 2-D MIPs for an example electrode-implanted animal (top half) and window-only control (bottom half). For each animal, slices parallel to the electrode path ($x-z$ view; $50\mu \mathrm{m}$) and perpendicular to it ($y-z$ view, $100\mu \mathrm{m}$) are shown. For the electrode-implanted animal, blue lines show the side view of the electrode (in the $x-z$ view), and a blue oval shows a cross section of the electrode (in the $y-z$ view). Severed dendrites in the electrode path are evident at 1 dpi, although dendritic tuft arborization remains complex immediately after this acute injury. Clear evidence of neurite fragmentation and reduced arborization is seen as early as 63 dpi, and dendrites do not recover a year postimplantation.