Fig. 8.

Angiography changes in deep capillaries from window and electrode implantation over 1 year. Each subpanel shows an example of the measurement (top) and the trends for window-only and electrode animals (bottom) over 1 year normalized to 1 dpi. Scale bar in all examples is $200\mu \mathrm{m}$. (a) Average capillary diameter measurements for window-only and electrode animals (two-way ANOVA test, $p=0.0015$). (b) Capillary density quantified by thresholded vessel pixels within large ($800\times 800\mu \mathrm{m}$) ROI ($p<{10}^{-14}$). (c) Sum of all gray-scale pixels within large ROI ($p<{10}^{-10}$). (d) Capillary density (vessel pixels) in annular ROIs near electrode with increasing proximity from electrode tip (ANOVA; $<100\mu \mathrm{m}$, $p<{10}^{-3}$; 100 to $200\mu \mathrm{m}$, $p<0.01$; 200 to $300\mu \mathrm{m}$, $p<{10}^{-20}$). (e) ROI pixel sum in annular ROIs ($<100\mu \mathrm{m}$, $p<0.005$; 100 to $200\mu \mathrm{m}$, $p<{10}^{-9}$; 200 to $300\mu \mathrm{m}$, $p<{10}^{-13}$). Shaded area for all figures indicates $\pm \mathrm{SEM}$.