Table 1:
Description of study cohort by cerebral edema (CED) group
| Variable | Total (n=738) | CED-3 (n=91) | CED-2 (n=47) | CED 0–1 (n=540) | p-value |
|---|---|---|---|---|---|
| Age | 70 (61–79) | 69 (58–77) | 72 (63–84) | 70 (61–79) | 0.14 |
| Gender, male | 375 (51%) | ||||
| Race, non-Caucasian | 83 (11%) | 17 (19%) | 7 (15%) | 41 (8%) | 0.01 |
| NIHSS, baseline | 8 (4–15) | 16 (13–19) | 18 (11–21) | 6 (4–12) | < 0.001 |
| tPA treatment | 538 (73%) | 64 (70%) | 31 (66%) | 389 (72%) | 0.12 |
| thrombectomy | 115 (16%) | 19 (21%) | 12 (26%) | 74 (14%) | 0.03 |
| NIHSS, 24hr | 5 (2–11) | 16 (10–21) | 15 (9–19) | 3 (1–8) | < 0.001 |
| CSF volume, baseline | 154 (109–205) | 132 (94–163) | 163 (111–198) | 160 (118–211) | < 0.001 |
| Glucose (mg/dl) | 121 (106–146) | 127 (115–157) | 123 (104–155) | 119 (104–144) | 0.02 |
| Blood pressure, systolic | 147±36 | 159±31 | 149±27 | 161±30 | 0.04 |
| Undetermined | 219 (30%) | 20 (23%) | 11 (23%) | 171 (31%) | |
| Outcomes | |||||
| MLS at 24-hour | 0 (0–0) | 2.8 (1.0–3.6) | 0 (0–0.2) | 0 (0–0) | < 0.001 |
| Peak MLS† | 0 (0–1.7) | 6.0 (3.8–10.0) | 0 (0–0.9) | 0 (0–0) | < 0.001 |
| Peak infarct volume (ml)† | 27 (0–81) | 238 (150–294) | 125 (90–154) | 2 (0–23) | < 0.001 |
| Hemicraniectomy | 17 (2%) | 17 (19%) | 0 | 0 | < 0.001 |
| In-Hospital Mortality | 32 (4%) | 16 (18%) | 5 (11%) | 6 (1%) | < 0.001 |
| Change in CSF % | 12% (5–23) | 36% (24–45) | 27% (18–40) | 10% (4–17) | < 0.001 |
| Rate of CSF change (ml/hr) | 1.0 (0.4–2.2) | 2.4 (1.4–3.4) | 2.0 (1.1–2.9) | 0.8 (0.3–1.4) | < 0.001 |
| Mrs 0–2 at 90d (n=670) | 392 (59%) | 19/82 (23%) | 11/40 (28%) | 335/499 (67%) | < 0.001 |
Continuous data are presented as medians (IQR); Kruskal-Wallis comparison for medians
†
Only for those with subsequent CTs available beyond 24-hours (n=211)