TABLE I.

VALIDATION RESULTS (F-SCORE) ON 15 2D PATHOLOGIC IMAGES

d	HDoG F-score	LoG F-score	HDoG vs. LoG p-value	gLoG F-score	HDoG vs. gLoG p-value	HLoG F-score	HDoG vs. HLoG p-value
0	0.049	0.041	0.051=	0.046	0.496=	0.042	0.071=
1	0.197	0.172	0.008+	0.193	0.696=	0.184	0.131=
2	0.405	0.348	0.000+	0.402	0.858=	0.385	0.154=
3	0.623	0.531	0.000+	0.616	0.708=	0.609	0.391=
4	0.738	0.634	0.000+	0.737	0.953=	0.731	0.648=
5	0.81	0.703	0.000+	0.816	0.687=	0.811	0.923=
6	0.847	0.738	0.000+	0.849	0.871=	0.849	0.842=
7	0.868	0.76	0.000+	0.867	0.877=	0.87	0.789=
8	0.885	0.777	0.000+	0.88	0.579=	0.886	0.860=
9	0.894	0.79	0.000+	0.891	0.702=	0.895	0.772=
10	0.901	0.801	0.000+	0.897	0.642=	0.904	0.544=
11	0.906	0.807	0.000+	0.903	0.643=	0.909	0.561=
12	0.911	0.813	0.000+	0.907	0.596=	0.915	0.512=
13	0.918	0.82	0.000+	0.912	0.419=	0.922	0.497=
14	0.923	0.827	0.000+	0.917	0.423=	0.928	0.370=
15	0.927	0.838	0.000+	0.921	0.456=	0.934	0.300=
16	0.931	0.849	0.000+	0.927	0.541=	0.938	0.322=

The normalizing factor γ =2 based on prior experiments. Detailed of the parameter setting please refer to ). Paired T-tests were performed at a significance level of 0.05. Symbols in cell means: + statistically outperformed; = Statistically Comparable; - Statistically Underperformed