TABLE II.

VALIDATION RESULTS (F-SCORE) ON 200 2D FLUORESCENT IMAGES

d	HDoG F-score	LoG F-score	HDoG vs. LoG p-value	gLoG F-score	HDoG vs. gLoG p-value	HLoG F-score	HDoG vs. HLoG p-value
0	0.07	0.075	0.014-	0.077	0.009-	0.105	0.233=
1	0.3	0.28	0.000+	0.317	0.009-	0.395	0.350=
2	0.586	0.471	0.000+	0.593	0.431=	0.696	0.283=
3	0.829	0.579	0.000+	0.796	0.002+	0.867	0.685=
4	0.89	0.61	0.000+	0.834	0.000+	0.887	0.741=
5	0.897	0.624	0.000+	0.837	0.000+	0.89	0.742=
6	0.898	0.628	0.000+	0.838	0.000+	0.89	0.995=
7	0.898	0.633	0.000+	0.838	0.000+	0.89	0.700=
8	0.898	0.642	0.000+	0.838	0.000+	0.89	0.475=
9	0.899	0.654	0.000+	0.838	0.000+	0.89	0.526=
10	0.899	0.669	0.000+	0.838	0.000+	0.89	0.323=
11	0.899	0.689	0.000+	0.838	0.000+	0.89	0.321=
12	0.9	0.713	0.000+	0.838	0.000+	0.891	0.250=

The normalizing factor γ =1 based on prior experiments. Details of the parameter settings are described in ). Paired T-tests were performed at a significance level of 0.05. + Statistically Outperformed; = Statistically Comparable; - Statistically Underperformed