Pastorelli 1991.

Methods	Single‐site study (Italy). Method of randomization/ allocation: NR Duration of treatment: single dose Follow‐up: 1 h
Participants	96 patients with hypertensive emergencies* Inclusion Criteria: Patients with observed hypertensive emergencies (*defined as acute target organ damage and high blood pressure). The different types of hypertensive emergencies were uniformly present in each group. No further details Exclusion Criteria: Not stated Not reported
Interventions	Nifedipine sublingual (N): n=16, Captopril sublingual (Cs): n=27, Captopril oral (Co): n=14, Ketanserine sublingual (K): n=15, Placebo (P):20 Dose Regimen: single dose.
Outcomes	Obtained from this trial: Total SAE: NR Mortality: NR Total non‐fatal CVE: NR Individual Cardiovascular events: NR Withdraw due to adverse events: N/A (single dose) Blood Pressure; Data was obtained from graphs in page 861 and 862. The calculated weighted mean BP change was: Nifedipine: SBP‐26.66±12.45; DBP‐18.16±9.13, Placebo: SBP‐7.2±13.5; DBP‐7.8±9 Ketanserine: SBP‐13.6±7; DBP‐14.6±9 Captopril: SBP‐22.56±9.32; DBP‐14.74±9 It was not specified if SD or SE was reported on the text or graphs. It was assumed to be SD. Standard deviation of change was not reported but imputed from end point
Notes	Funding: Not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear