| Study | Reason for exclusion |
|---|---|
| Annane 1996 | Only responders to an immediate previously given antihypertensive treatment . Thus, the results of this trials cannot be generalize to another situations. |
| Bertel 1983 | It does not report any of the outcome of interest, actually it does not show results of the clonidine group. Baseline values are not separated according to the randomization groups . |
| Borghi 1999 | BP was not part of inclusion criteria; and BP at baseline was too low (143/88 mmHg) for our acute myocardial infarction threshold (180/110 mm Hg) |
| Bussmann 1992 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate beteween those. |
| Ceyhan 1990 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Conen 1988 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Cotter 1998 | It compares wrong comparators: two different doses of a combination regimen |
| Dadkar 1993 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Franklin 1986 | Results from patients non‐randomized were mixed with randomized patients |
| Guerrera 1990 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Lisk 1993 | Blood pressure inclusion criteria (>170 mmHg) and baseline bp values, 172‐178/98‐104 (calculated from MAP 122‐128 mm Hg) were lower than our blood pressure thershold, 180/110, for acute stroke. |
| Marghli 1997 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Moritz 1989 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Nelson 1984 | It is a cross over trial |
| Neutel 1994 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those |
| Nielsen 1980 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Panacek 1995 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Pascale 1992 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Perez 1991 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Pilmer 1993 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Pujadas 1987 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Reisin 1990 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
| Risler 1998 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Rohr 1994 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Spah 1988 | Hypertensive emergency and non‐emergency patients are mixed in the same trial. Results do not discriminate those. |
| Yoshida 1998 | It was excluded because it compared two drugs of the same class (calcium channel blocker). Note: this is the only trial found that studied exclusively patients with acute aortic dissection. |
| Zampaglione 1994 | It was not possible to determine whether the population studied included exclusively patients with acute end organ damage |
AEOD: Acute end organ damage SBP= systolic blood pressure DBP= diastolic blood pressure