Fig 4. Neutralizing antibody response against PV1-S.
Anti-PV1 neutralization titers from groups of 8 rats immunized with irradiated 1 × or 1/2 × human dose of IPOL (blue circle), VeroPol (red square), IR-inactivated PV1-S (black triangle) or irradiated PV1-S without MDP (purple circle) are shown here. Neutralization titers for D49 are presented as Log2 values. Sera from rats immunized with a saline control had titers below the limit of detection. Horizontal lines indicate mean neutralization values for each group and each data point represents an individual animal within the group. P values from unpaired one-tailed t-tests comparing Ir-PV1-S to either IPOL or VeroPol are indicated. P values above 0.05 are not shown. Ir-PV1-S, gamma-irradiated PV1-S. The results reflect serological analyses from the sera from one animal immunization study.