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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Colloid Interface Sci. 2018 Sep 22;535:133–148. doi: 10.1016/j.jcis.2018.09.072

Figure 7. TAP NPs stabilize β-tubulins in breast cancer cells.

Figure 7.

A) β-tubulin stabilization assay representing confocal images after treatment with 5 and 10 nmol/L PTX or PTX equivalent TAP NPs for 8 hours on MDA-MB-231. Distinct bundles of microtubules were seen in control cells suggesting their proliferating nature, which changed to thicker clusters of microtubules after treatment with TAP NPs and PTX, suggesting stabilization of microtubules accounting for the innate nature of the taxane drug (scale = 20 μm). B) Quantitative analysis of the florescent intensity by Image J software shows significant lower Mean Intensity (arbitrary units) in contrast to TAP NPs. Data represented as mean ± standard error of the mean (n = 3).