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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Colloid Interface Sci. 2018 Sep 22;535:133–148. doi: 10.1016/j.jcis.2018.09.072

Figure 8. Molecular mechanism of TAP NPs in inducing apoptosis in breast cancer cells.

Figure 8.

A) Western blot analysis of whole cell lysates of MDA-MB-231 that was treated with 10 nmol/L PTX or 10 nmol/L PTX equivalent TAP NPs and their respective controls for 48 hours and immunoblotted for Cleaved PARP, MDR1/ABCB1, Cleaved Caspase-7, p53, Bad, Bcl-xL and β-actin. The results were consistent in two independent sets of experiments. B) Heat map of differentially regulated gene expression of pro-apoptotic and anti-apoptotic signaling leading to apoptosis in MDA-MB-231 breast cancer cells after exposure to TAP NPs. C) Heat map representing gene expression of ABC family.