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Formation and optimization of TAP NPs: A) Space-filling energy-minimized (MM2) molecular modeling shows generation of thermodynamically stable TA-PTX self-assembly. Various ratios as shown above were employed to generate MM2 models of TA-PTX self-assembly. B) Hypothetical representation of 24:1 ratio of TA: PTX self- assembly, so called Tannic acid Nanoparticles (TAP NPs). For visual clarity, PTX in hypothetical structure is represented as.
