Table 2.
Cases n=57* | Controls n=15* |
|
---|---|---|
Gender | ||
Female | 52 (92%) | 11 (73%) |
Male | 5 (9%) | 4 (27%) |
Race | ||
Asian | 7 (12%) | 0 |
Black/African American | 23 (40%) | 3 (20%) |
Unknown or not reported | 3 (5%) | 1 (7%) |
White | 25 (43%) | 11 (73%) |
Ethnicity | ||
Hispanic or Latino | 17 (30%) | 2 (13%) |
Not Hispanic | 40 (70%) | 13 (87%) |
Age at biopsy (years) | 31.93 ± 10.50 | 35.54 ± 6.27 |
Medication | ||
Belimumab | 3 (5%) | |
Prednisone | 39 (68%) | |
Hydroxychloroquine | 51 (89%) | |
Methotrexate | 1 (2%) | |
Mycophenolic Acid | 1 (2%) | |
Mycophenolate mofetil | 14 (25%) | |
dsDNA+ (n=48) | 40 (83%) | |
Low C3 (n=56) | 42 (75%) | |
Low C4 (n=56) | 37 (66%) | |
ISN Class** | ||
[I] | 1 (2%) | |
[II] | 2 (4%) | |
[II][V] | 1 (2%) | |
[III] | 10 (17%) | |
[III][V] | 9 (16%) | |
[IV] | 9 (16%) | |
[IV][V] | 10 (17%) | |
[V] | 15 (26%) | |
Activity (n=37) | 4.69 (SEM: 0.78; Range: 0–16) † | |
Chronicity (n=37) | 1.95 (SEM: 0.29; Range: 0–7) ‡ | |
ACR 1997 Score (n=57) | 5.84 | |
SLICC Score (n=51) | 7.80 | |
SELENA-SLEDAI (n=57) | 12.93 | |
SLICC Damage Index (n=51) | 3.99 |
45 LN and 12 LD controls analyzed in Phase 1 and the others rolled over to Phase 2
Class VI biopsies were excluded
Maximum 24
Maximum 12