Table 1.
Demographics and optic neuritis history characteristics.
| AQP4-ON | MOG-ON | MS-ON | HC | P-value | |
|---|---|---|---|---|---|
| Subjects (eyes) | 48 (74) | 16 (27) | 40 (47) | 31 (62) | |
| Age, years, mean (SD) | 43.7 (12.7) | 43.8 (13.3) | 41.5 (12.6) | 41.5 (14.1) | 0.81 |
| Female sex, n (%) | 43 (90%) | 12 (75%) | 28 (70%) | 22 (71%) | 0.08 |
| Race, n (%)a | |||||
| Caucasian American | 23 (48%) | 11 (69%) | 24 (60%) | 24 (77%) | |
| African American | 23 (48%) | 3 (19%) | 15 (38%) | 5 (16%) | 0.04 |
| Other | 2 (4%) | 2 (13%) | 1 (3%) | 2 (6%) | |
| Microcystoid macular pathology, eyes, n (%) | 14 (19%) | 3 (11%) | 3 (6%) | - | 0.12 |
| Microcystoid macular pathology, patients, n (%) | 12 (26%) | 2 (13%) | 3 (8%) | - | 0.08 |
| Episodes of ON per eye, median (range) | 1 (1-5) | 2 (1-16) | 1 (1-2) | - | <0.001 |
| Time since initial ON (by eye), years, median (IQR)b | 5.9 (2.1-10.4) | 2.1 (1.0-3.1) | 4.6 (2.1-7.7) | - | <0.001 |
| Time since last ON (by eye), years, median (IQR)b | 4.8 (1.6-7.7) | 0.8 (0.4-3.1) | 4.1 (2.1-7.1) | - | <0.001 |
a
The sum of percentages is not 100% due to rounding
b
Time since initial/last ON refers to time elapsed from ON to OCT and visual function testing.
Abbreviations: ON: optic neuritis; AQP4-ON: aquaporin-4-IgG seropositive ON; MOG-ON: myelin oligodendrocyte glycoprotein-IgG seropositive ON; MS-ON: multiple sclerosis ON; HC: healthy control; OCT: optical coherence tomography; SD: standard deviation; IQR: interquartile range