Table 3.
Comparison of optical coherence tomography measures and letter-acuity scores between groups
| AQP4-ON vs. MOG-ON |
AQP4-ON vs. MS-ON |
MOG-ON vs. MS-ON |
AQP4-ON vs. HC |
MOG-ON vs. HC |
MS-ON vs. HC |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Betad (95% CI) |
P | Betad (95% CI) |
P | Betad (95% CI) |
P | Betad (95% CI) |
P | Betad (95% CI) |
P | Betad (95% CI) |
P | |
| OCT measures, μm | ||||||||||||
| Global pRNFLa | 6.0 (−0.5 to 12.5) |
0.07 |
−11.5 (−16.8 to −6.3) |
<0.001 |
−17.5 (−23.8 to −11.2) |
<0.001 |
−24.1 (−29.3 to −18.8) |
<0.001 |
−30.1 (−36.3 to −23.8) |
<0.001 |
−12.5 (−17.5 to −18.8) |
<0.001 |
| Superior quadranta | 6.8 (−2.7 to 16.3) |
0.16 |
−20.5 (−28.8 to −12.2) |
<0.001 |
−27.3 (−36.8 to −17.7) |
<0.001 |
−34.1 (−41.8 to −26.4) |
<0.001 |
−40.9 (−49.9 to −31.9) |
<0.001 |
−13.6 (−21.4 to −26.4) |
0.001 |
| Nasal quadranta | 2.4 (−1.7 to 6.6) |
0.25 |
−5.6 (−9.3 to −1.9) |
0.001 |
−8.0 (−12.2 to −3.9) |
<0.001 |
−11.9 (−16.7 to −7.0) |
<0.001 |
−14.3 (−19.5 to −9.1) |
<0.001 |
−6.3 (−11.1 to −7.0) |
0.01 |
| Inferior quadranta | 5.4 (−5.9 to 16.8) |
0.35 |
−21.9 (−31.2 to −12.6) |
<0.001 |
−27.3 (−37.9 to −16.7) |
<0.001 |
−39.5 (−49.0 to −30.0) |
<0.001 |
−44.9 (−55.7 to −34.2) |
<0.001 |
−17.6 (−26.1 to −30.0) |
<0.001 |
| Temporal quadranta |
9.1 (3.1 to 15.1) |
0.003 | 1.8 (−2.8 to 6.4) |
0.43 |
−7.2 (−13.2 to −1.3) |
0.02 |
−11.2 (−15.9 to −6.5) |
<0.001 |
−20.2 (−26.3 to −14.2) |
<0.001 |
−13 (−17.7 to −6.5) |
<0.001 |
| GCIPLb | −1.6 (−5.5 to 2.3) |
0.43 |
−9.1 (−13.1 to −5.1) |
<0.001 |
−7.6 (−11.9 to −3.2) |
0.001 |
−21.0 (−23.9 to −18) |
<0.001 |
−19.4 (−22.8 to −16.0) |
<0.001 |
−11.8 (−15.4 to −18.0) |
<0.001 |
| INLb | −0.5 (−2.7 to 1.6) |
0.62 | −0.6 (−2.5 to 1.2) |
0.50 | −0.1 (−2.4 to 2.2) |
0.93 | −1.1 (−2.5 to 0.3) |
0.14 | −0.5 (−2.5 to 1.5) |
0.60 | −0.4 (−2.2 to 0.3) |
0.62 |
| ONLb |
−3.4 (−6.6 to −0.2) |
0.04 |
−3.7 (−6.2 to −1.2) |
0.004 | 1.1 (−3.0 to 5.2) |
0.61 |
−3.2 (−5.9 to −0.6) |
0.02 | 0.1 (−3.4 to 3.6) |
0.95 | 0.5 (−2.4 to 3.4) |
0.75 |
| Letter-acuity scoresc | ||||||||||||
| 100% contrast (HCLA) |
−22.3 (−30.0 to −14.7) |
<0.001 |
−21.7 (−29.4 to −14.0) |
<0.001 | 0.6 (−5.5 to 6.7) |
0.85 |
−28.0 (−34.7 to −21.3) |
<0.001 |
−5.7 (−10.4 to −1.0) |
0.02 |
−6.3 (−11.1 to −1.4) |
0.01 |
| 2.5% contrast (LCLA) | −3.1 (−8.7 to 2.5) |
0.28 |
−14.7 (−19.4 to −9.9) |
<0.001 |
−11.6 (−17.7 to −5.5) |
<0.001 |
−23.0 (−27.0 to −19.1) |
<0.001 |
−20.0 (−25.4 to −14.5) |
<0.001 |
−8.4 (−13.0 to −3.7) |
0.001 |
Available for 65 AQP4-ON, 27 MOG-ON, 47 MS-ON and 60 HC eyes
Available for 69 AQP4-ON, 27 MOG-ON, 47 MS-ON and 59 HC eyes
Available for 56 AQP4-ON, 21 MOG-ON, 47 MS-ON and 58 HC eyes
Results are derived from unadjusted linear generalized estimating equations (GEE) models. For OCT measures, the beta coefficients correspond to difference in μm between groups. For letter-acuity scores, the beta coefficients correspond to difference in number of letters correct between groups.
Abbreviations: ON: optic neuritis; AQP4-ON: aquaporin-4-IgG seropositive ON; MOG-ON: myelin oligodendrocyte glycoprotein-IgG seropositive ON; MS-ON: multiple sclerosis ON; HC: healthy control; CI: confidence interval; pRNFL: peri-papillary retinal nerve fiber layer; GCIPL: ganglion cell+inner plexiform layer; INL: inner nuclear layer; ONL: outer nuclear layer; HCLA: high-contrast letter-acuity; LCLA: low-contrast letter acuity