Table 4.
Comparison of optical coherence tomography measures and letter-acuity scores between eyes matched to the MOG-ON group on high-contrast letter acuity.
| AQP4-ON (n=21 eyes) |
MOG-ON (n=21 eyes) |
MS-ON (n=21 eyes) |
AQP4-ON vs. MOG-ON | AQP4-ON vs. MS-ON | MOG-ON vs. MS-ON | ||||
|---|---|---|---|---|---|---|---|---|---|
| Beta* (95% CI) | P-value | Beta* (95% CI) | P-value | Beta* (95% CI) | P-value | ||||
| OCT measures, um, mean(SD) | |||||||||
| Global pRNFL | 76.5 (17.9) | 61.2 (11.7) | 79.6 (11.8) | 17.2 (7.2 to 27.3) | 0.001 | −1.1 (−10.7 to 8.5) | 0.82 | −18.4 (−26.3 to −10.4) | <0.001 |
| Superior quadrant | 96.7 (25.0) | 73.1 (17.2) | 101.9 (20.3) | 25.9 (11.8 to 40.1) | <0.001 | −2.9 (−17.2 to 11.4) | 0.69 | −28.9 (−41.2 to −16.5) | <0.001 |
| Nasal quadrant | 62.6 (13.0) | 56.6 (7.2) | 64.6 (8.8) | 6.9 (0 to 13.8) | 0.05 | −0.8 (−7.9 to 6.3) | 0.82 | −7.7 (−12.8 to −2.6) | 0.003 |
| Inferior quadrant | 98.5 (35.9) | 74.5 (18.1) | 102.3 (21.5) | 26.2 (7.1 to 45.2) | 0.007 | −2.0 (−21.0 to 16.9) | 0.83 | −28.2 (−41.8 to −14.7) | <0.001 |
| Temporal quadrant | 47.8 (10.0) | 41.2 (11.3) | 49.4 (9.4) | 7.7 (0 to 15.3) | 0.049 | −0.3 (−6.4 to 5.8) | 0.92 | −7.9 (−15.6 to −0.3) | 0.04 |
| GCIP | 63.6 (9.3) | 56.5 (6.9) | 64.7 (11.1) | 7.6 (2.1 to 13.0) | 0.006 | −0.8 (−7.1 to 5.4) | 0.80 | −8.4 (−14.4 to −2.4) | 0.006 |
| INL | 44.2 (2.8) | 44.3 (4.0) | 44.4 (6.7) | −0.3 (−2.8 to 2.3) | 0.84 | −0.5 (−3.7 to 2.7) | 0.76 | −0.2 (−4.0 to 3.5) | 0.90 |
| ONL | 67.2 (4.5) | 68.4 (5.6) | 68.2 (12.7) | −1.2 (−4.9 to 2.6) | 0.54 | −1.0 (−7.1 to 5.0) | 0.74 | 0.1 (−6.3 to 6.6) | 0.97 |
| Letter-acuity scores, median (IQR) | |||||||||
| 100% contrast (HCLA) | 56 (53-59) | 57 (53-60) | 57 (53-60) | 0.0 (−5.9 to 5.8) | 0.99 | −0.5 (−6.2 to 5.3) | 0.87 | −0.4 (−6.6 to 5.7) | 0.89 |
| 2.5% contrast (LCLA) | 24 (8-30) | 11 (3-15) | 27 (18-30) | 8.4 (1.2 to 15.5) | 0.02 | −2.3 (−9.5 to 5.0) | 0.54 | −10.6 (3.7 to 17.5) | 0.002 |
*
For OCT measures corresponds to difference in μm between groups. For letter-acuity scores corresponds to difference in number of letters correct between group.
Abbreviations: ON: optic neuritis; AQP4-ON: aquaporin-4-IgG seropositive ON; MOG-ON: myelin oligodendrocyte glycoprotein-IgG seropositive ON; MS-ON: multiple sclerosis ON; CI: confidence interval; pRNFL: peri-papillary retinal nerve fiber layer; GCIPL: ganglion cell+inner plexiform layer; INL: inner nuclear layer; ONL: outer nuclear layer; HCLA: high-contrast letter-acuity; LCLA: low-contrast letter acuity