Figure 2.

Imaging mass spectrometry can be used to identify spatial distribution of metabolites from a variety of samples, such as plants, animals, and microbes. (i) DESI-IMS of Lotus japonicus cyd1, MG-20, and cyd2–2 leaves showing m/z 286. Figure adapted with permission under Creative Commons Attribution 3.0 Unported (CC BY 3.0).¹⁰ (ii) LAESI-IMS on pansy leaf showing elphinidin-3-p-coumaroylr-hamnosylglucoside-5-glucoside (m/z 919.3). Reprinted (adapted) with permission from Vaikkinen et al. Copyright 2013 American Chemical Society.¹¹ (iii) DART-IMS on Datura leichhardtii seed showing m/z 163.0753. Reprinted (adapted) with permission from Fowble et al. Copyright 2017 American Chemical Society.¹² (iv) LESA-IMS on rat liver tissue sections of moxifloxacin (m/z 402.1823) at 2 hours. Figure adapted with permission under Creative Commons International 4.0 (CC BY 4.0).¹³ (v) IR-MALDESI-IMS on cancerous hen ovarian tissue sections showing glutathione (m/z 306.0766). The analyst online by Society of Public Analysts (Great Britain) Nazari et al. Reproduced with permission of Royal Society of Chemistry.¹⁴ (vi) MALDI-TOF-IMS on Glutamicibacter arilaetensis and Penicillium #12 co-culture for m/z 655.2. Figure adapted with permission under Creative Commons International 4.0 (CC BY 4.0).¹⁵ (vii) SALDI-IMS on Aspergillus 3Y of fellutamide C sodium adduct (m/z 580). Reprinted (adapted) with permission from Chen et al. Copyright 2018 American Chemical Society.¹⁶ (viii) SIMS imaging on Pseudomonas aeruginosa PAO1C biofilm at 72 hours (m/z 288.20). Reprinted (adapted) with permission from Dunham et al. Copyright 2018 American Chemical Society.¹⁷