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. Author manuscript; available in PMC: 2021 Feb 26.
Published in final edited form as: Nat Prod Rep. 2020 Feb 26;37(2):150–162. doi: 10.1039/c9np00038k

Figure 4.

Figure 4

(A) In MALDI and SALDI experiments, matrix is applied to a sample and allowed to co-crystallize on a conductive surface. A UV laser shot at the sample/matrix facilitates soft ionization by transferring energy from the laser to the analyte to form ions that are guided to the mass spectrometer for analysis. (B) LAESI and IR-MALDESI experiments have samples that contain frozen water. An IR laser shot at the sample releases/desorbs the analyte, which is then ionized by ESI before being taken up by the mass spectrometer for analysis.