Table 2.

The table shows the stability results predicted by different servers and softwares (DUET, ENCoM, DynaMut, mCSM, SDM, and FoldX).

Index	Mutation	DUET	ΔΔG ENCoM	ΔΔG DynaMut	mCSM ΔΔG	SDM ΔΔG	FoldX	Outcome
1.	K303R	0.116	−0.025	−0.217	−0.719	−0.17	−0.03	Stabilizing
2.	E380Q	−1.192	0.03	0.416	−1.482	−0.4	−0.29	Destabilizing
3.	D538G	−0.445	0.028	0.265	0.008	−0.54	0.92	Destabilizing
4.	Y537S	−1.899	−0.027	−0.095	−0.215	−0.39	3.22	Destabilizing
5.	Y537N	−1.369	−0.809	−0.077	−0.315	−1.66	2.41	Destabilizing
6.	H524E	−0.243	−0.087	−0.198	−0.73	−0.11	2.02	Destabilizing
7.	V392I	−0.431	−0.6	−1.726	−0.264	0.16	−0.86	Stabilizing
8.	S463P	−0.495	−0.606	−1.188	−0.689	−0.09	3.69	Destabilizing
9.	P535H	−0.036	−0.08	−0.056	−0.312	−1.1	1.65	Destabilizing
10.	L536H	−0.044	−0.413	−0.174	−0.788	−0.77	0.16	Stabilizing
11.	Y537C	−0.566	−0.559	0.076	−0.164	0.27	2.22	Destabilizing