Table 1.
Demographics and treatment characteristics of included couples.
| Characteristics | N | Median | 95% CI |
|---|---|---|---|
| Female age (years) | 1,464 | 39.4 | 33.0–44.0 |
| Male age (years) | 1,464 | 42.0 | 33.0–52.0 |
| BMI, female (kg/m2) | 1,464 | 24.8 | 19.0–34.0 |
| BMI, male (kg/m2) | 333 | 26.9 | 21.6–33.1 |
| Infertility factor, N (%) | |||
| Male factor | 252 (17.2) | – | – |
| Unexplained | 544 (37.2) | – | – |
| Endometriosis | 58 (3.9) | – | – |
| Endocrine/Anovulatory | 106 (7.2) | – | – |
| Anatomic/Tubal | 55 (3.7) | – | – |
| >1 type | 449 (30.8) | – | – |
| Baseline FSH (UI/mL) | 408 | 8.6 | 4.6–14.8 |
| Ovarian reserve marker | |||
| AFC (n) | 1,464 | 9.3 | 2–22 |
| AMH (ng/mL) | 1,287 | 2.0 | 0.2–6.8 |
| Semen parameters | |||
| Sperm count (M/mL) | 1,464 | 38.9 | 0.0–100.0 |
| Total motility (%) | 1,395 | 52.0 | 20.0–75.0 |
| Sperm morphology (%) | 797 | 3.8 | 1.0–8.0 |
| DFI (%) | 179 | 21.5 | 7.0–50.0 |
| Azoospermia, N (%) | 69 (4.7) | ||
| Non-obstructive; N (%) | 35 | – | – |
| Obstructive; N (%) | 34 | – | – |
| Poor ovarian reserve, N (%) | 482 (32.9) | – | – |
| Male factor associated (%) | 458 (31.3) | – | |
| Type of ovarian stimulation | |||
| Conventional ovarian stimulation; N (%): | 1,366 (93.3) | – | – |
| Minimal stimulation, N (%) | 98 (6.7) | – | – |
| Type of gonadotropin; N (%) | |||
| rFSH monotherapy | 513 (35.1) | – | |
| rFSH + rLH | 296 (20.2) | – | |
| rFSH + hMG | 538 (36.7) | – | |
| hMG alone | 97 (6.6) | – | |
| None | 20 (1.4) | – | |
| Total gonadotropin dose (IU) | 1,464 | 3,060.4 | 850.0–4,950.0 |
| Sperm source for ICSI; N (%) | |||
| Ejaculate | 1,358 (92.7) | – | – |
| Epididymis | 17 (1.3) | – | – |
| Testicle | 89 (6.0) | – | – |
| Ejaculated sperm; N (%) | |||
| Homologous; normal | 761 (56.1) | – | – |
| Homologous; abnormal | 587 (43.2) | – | – |
| Heterologous | 10 (0.7) | – | – |
| Gamete status for ICSI; N (%) | |||
| Fresh, sperm [S] + oocyte [O] | 1,388 (94.8) | – | – |
| Cryopreserved [S + O] | 0 (0.0) | – | – |
| Combined, fresh [S] + vitrified-warmed [O] | 7 (0.5) | – | – |
| Combined, frozen-thawed [S] + fresh [O] | 69 (4.7) | – | – |
| Oocyte and embryo parameters | 1,464 | ||
| No. Oocytes retrieved | 8.8 | 1.0–22.0 | |
| No. Mature (MII) oocytes | 6.7 | 1.0–16.0 | |
| No. Fertilized oocytes (2PN) | 4.8 | 0.0–12.0 | |
| No. Blastocysts | 2.1 | 0.0–6.0 | |
| No. Euploid blastocysts | 0.9 | 0.0–4.0 |
BMI, body mass index; AFC, antral follicle count; AMH, anti-Müllerian hormone; DFI, Sperm DNA fragmentation index; FSH, follicle stimulating hormone; POR, poor ovarian reserve defined according to the POSEIDON criteria, namely, antral follicle count (AFC) <5 and/or AMH hormone <1.2 ng/mL; 2PN, two pronuclei zygote; MII, metaphase II.